Enter through the main entrance of the hospital No appointments necessary. For questions or more information call 252.436.1605 The American Cancer Society (ACS), among many other organizations, recommends an annual serum PSA testing and a DRE starting by age 50 for men with a life expectancy of at least 10 years. Men at higher risk, such as those of African-American ancestry and those with a family history, should start screening at the age of 45.